Creatinine clearance (Cockcroft-Gault)

Cockcroft-Gault estimates creatinine clearance in mL/min. Most drug labels, including DOACs and many antibiotics, base renal dose adjustments on it rather than eGFR.

What goes into the Creatinine clearance (Cockcroft-Gault)

Age (years)
Weight (kg)
Creatinine (mg/dL)
Sex: Male; Female
Height (optional) (cm)

How to interpret the result

CrCl = (140 − age) × weight ÷ (72 × creatinine), × 0.85 if female
Shown with actual, ideal and (if over 120% of ideal) adjusted body weight

Clinical pearls

Unreliable when creatinine is changing (AKI) and in very low muscle mass.
Check which weight your institution's pharmacy uses for dosing in obesity.

Evidence

Cockcroft DW, Gault MH. Prediction of creatinine clearance from serum creatinine. Nephron. 1976;16:31-41.

Related workups

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Related calculators

eGFR (CKD-EPI 2021)CHA₂DS₂-VASc All calculators

For education only. Check the inputs and the population the score was validated in before acting on it. Not a substitute for clinical judgment.